"These data support the hypothesis that a primary mechanism for apoE-mediated plaque formation may be a result of apoE aggregation, as preferentially targeting of apoE aggregates with therapeutic ...
A flurry of recent studies implicating microglia as key players in neurodegenerative diseases, particularly Alzheimer’s, has cued many labs to try to figure out how these cells function in health, and ...
The APOE ε4 allele was linked to clinical expression and biomarkers of Alzheimer's disease in people with Down syndrome, a dual-center cohort study showed. Among 464 adults with Down syndrome, APOE ε4 ...
People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer’s disease. Now, researchers at Washington University School of Medicine in St. Louis have identified a ...
Schemes are in the works to treat Alzheimer’s disease by targeting its most potent genetic risk factor, ApoE4, but could depleting ApoE from the brain cause serious side effects? Not if a 40-year-old ...
A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human microglia function in Alzheimer's disease. The study, led by Dr Sarah Marzi and ...
Latin name: Ovis aries. Breed is unknown. Sheep are the most widely distributed domestic animal around the world. There are more than 200 breeds and they are raised for their wool, meat and milk. This ...
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