Checkpoint inhibitors are antibody-based cancer therapies that unlock the immune system’s natural ability to fight cancer. These treatments work by blocking special proteins called immune checkpoints, ...

PD-1 checkpoint proteins on T cells (blue) can bind to two different receptors: PD-L1 and PD-L2. There are many ways to climb a mountain. This saying especially rings true in cancer research, where ...

Among modern cancer therapies, immune checkpoint inhibitors (ICI) are among the most successful treatment methods. These ...

A Cleveland Clinic-led team of scientists and physicians has discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T cells during immunotherapy and resist treatment.

The result is one molecule that can be both a checkpoint degrader and a cancer vaccine ( Nature 2026, DOI: 10.1038/s41586-025 ...

A research team led by Professor Chen Peng from the College of Chemistry and Molecular Engineering at Peking University has ...

All the things that define AD pathogenesis—the seeding and growth of Aβ plaques, withering of surrounding synapses, propagation of tau tangles, and infiltration of circulating immune cells into the ...

Immune checkpoint molecules play a crucial role in keeping the immune system in balance and preventing an attack on the body's own cells. Cancer cells can use these checkpoints to hide from the immune ...

Our immune system guards against cancer development by constantly surveilling the body and eliminating unhealthy cells. Immune cells are highly suspicious of other cells. While this leads to a swift ...