DNA, though tightly packed in the nucleus, is constantly threatened by damage from metabolism and external stressors. One particularly severe form of DNA damage is the so-called DNA–protein crosslinks ...
Study: Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER. Image Credit: Anusorn Nakdee/Shutterstock.com In a recent study published in Nature ...
Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature ...
A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...
Figure 6. Senescent heterogeneity model based on DNA content. Compared to G1-arrested cells, G2-arrested senescent cells express higher levels of senescence-associated markers, secrete more IL-6, and ...
Notably, inhibition of cGAS-STING from early development rescued mice from developmental lethality and premature aging caused ...
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