One of the hallmarks of Alzheimer's disease is the clumping of proteins called Tau, which form tangled fibrils in the brain.

ProtoBind-Diff generates drug-like molecules for specific protein targets using only their amino acid sequences—no 3D structures required. The model performs competitively with leading structure-based ...

MIT chemists used NMR spectroscopy to reveal the disordered “fuzzy coat” surrounding Tau protein fibrils, offering new ...

Protein scientists could improve reproducibility and coordination across the field by rallying around a small, shared set of ...

A new artificial intelligence model can predict how different proteins may bind to DNA. A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how ...

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

Prof. Liu Cong from the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences, along with collaborators, ...

Scientists in Jennifer Doudna’s lab at Gladstone Institutes and the Innovative Genomics Institute provide novel insights into nearly 70,000 lesser-known viral proteins that could eventually help in ...