Researchers have used a combination of genetic manipulation and protein structural analysis to determine how the position of 'bulky' amino acids influences the ability of efflux pump inhibitors to ...
Multidrug resistance in Gram-negative bacteria represents a major public health challenge, with these organisms evolving a myriad of mechanisms to evade the effects of antibiotic treatment. One ...
image: The inhibitor-binding site of the wild-type MexB pump. (a) The crystal structure of the inhibitor ABI-PP bound to the MexB trimer. Three MexB monomers are shown in green, blue, and red, ...
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