Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Two different versions of the mu-opioid receptor within a cellular membrane illustrate how the receptor changes its conformation to send a signal into the cell. Scientists captured six high-resolution ...

Opioids slot into opioid receptors and activate them. This sends signals to your brain to relieve pain and promote pleasure. Both endogenous opioids, which your body naturally produces, and exogenous ...

Two different versions of the mu-opioid receptor within a cellular membrane illustrate how the receptor changes its conformation to send a signal into the cell. Disclaimer: AAAS and EurekAlert! are ...

Researchers identified the structure of an opioid receptor in the brain during active engagement with a drug molecule. The discovery could facilitate the creation of safer and more effective opioid ...

For decades, opioids have been the blunt instrument of modern pain care, powerful enough to quiet severe suffering yet risky enough to fuel a global overdose crisis. Now a wave of basic science and ...

Researchers at USF Health have discovered a new way opioid receptors can work that may lead to safer pain medications. Their findings show that certain experimental compounds can amplify pain relief ...

(THE CONVERSATION) Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States’ fight against the opioid crisis. It reverses an opioid overdose nearly ...

Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...