New research from WashU Medicine identified a key enzyme, called FA2H, that enables rotavirus to infect cells. When rotavirus enters a cell without FA2H, it becomes trapped in pockets called endosomes ...

Rotavirus is a leading cause of severe gastroenteritis and diarrhea globally, and nearly all children have been infected with rotavirus by age 5 years. Until a safe, effective vaccine for rotavirus ...

The introduction of the rotavirus vaccine has had a profound impact on global pediatric deaths from acute gastroenteritis and diarrhea, but its footprint has been uneven and challenging to track ...

Of all the diseases that the U.S. government announced today that it will no longer recommend vaccines against, rotavirus is by no means the deadliest. Not all children develop substantial symptoms; ...

Researchers have shown that differences in the entire rotavirus genome -- not just its two surface proteins -- affect how well vaccines work, helping to explain why some strains are more likely to ...

Background.Rotavirus disease rates dramatically declined among children <5 years of age since the rotavirus vaccine was introduced in 2006; population-level impacts remain to be fully elucidated.