Temporary protein-protein bonds are essential for processes including enzymatic reactions, antibody binding, and response to medication. Being able to accurately characterize these bonds is important ...

Atomic Force Microscopy-based SMFS is widely used due to its high force sensitivity and spatial resolution. In this technique, a biomolecule is attached between a surface and an AFM cantilever. As the ...

Using advanced imaging techniques and precise microfluidics control to stretch out curly DNA into a straight line, new research demonstrates techniques for stretching and immobilizing DNA with minimum ...

Force spectroscopy relies on the precise measurement of forces acting on a probe as it interacts with a sample. The key principles of force spectroscopy include: AFM-based force spectroscopy is the ...

Single-molecule DNA detection using nanopore technology offers real-time analysis of DNA and RNA strands. It is a low-cost and flexible technique that can be used in clinical and research settings ...

The precise measurement of thermodynamic and kinetic properties for biomolecules provides the detailed information for a multitude of applications in biochemistry, biosensing, and health care. However ...

The authors used a combination of super-resolution imaging techniques and liquid pressure flow to fine-tune the stretch ratio of a DNA molecule, improving the lateral resolution of side-by-side ...