Since statins first came to market in the late 1980s, muscle aches, weakness, and fatigue have driven many patients to ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these ...

A team of researchers has found that mutations in the calcium channel protein RyR1 that confer susceptibility to malignant hyperthermia make the protein hypersensitive to heat, which triggers ...