The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. [5] As such, p53 has been described as …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells …

Jun 29, 2025 · The p53 protein, often called “the guardian of the genome,” is a tumor suppressor that helps prevent cells from becoming cancerous. As a transcription factor, it can bind to DNA …

Mar 1, 2023 · The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle, apoptosis, and genomic stability, …

Jan 1, 2025 · We propose a model for how DNA binding by p53 is regulated by its disordered regions. Defects in the tumor suppressor protein p53 are found in the majority of cancers.

Jul 27, 2025 · Exploring the diverse roles of p53, which include regulating the cell cycle, repairing DNA, inducing apoptosis, reprogramming metabolism, and modulating immunity, provides …

May 10, 2025 · p53 involved in the regulation of energy metabolism and antioxidant function. Fischer (2017) complement this finding by listing 3,661 direct target genes of p53, a significant …

The p53 protein is a sequence-specific DNA-binding transcription factor that, in response to stressful stimuli, regulates gene expression related to multiple cellular functions including, but …

Apr 5, 2025 · The p53 gene, also known as the TP53 gene, provides instructions for making a protein called the tumour protein p53, or simply p53. This protein acts as a tumour suppressor, …