Gastrin (stimulates/inhibits) the secretion of acid by the stom... | Filo
Gastrin (stimulates/inhibits) the secretion of acid by the stom... | Filo
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MedLearn on Instagram: "Proton Pump Inhibitors (PPIs) are the most effective drugs for reducing gastric acid secretion. They act directly on the parietal cells of the stomach, where acid is produced. Inside the parietal cell membrane is an enzyme called H⁺/K⁺ ATPase, also known as the proton pump. This pump is responsible for the final and most important step of acid production. PPIs irreversibly inhibit this proton pump, which leads to a 90–95% reduction in acid secretion, regardless of whether
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Proton pump inhibitors are effective medications — and they absolutely have a role. But long-term, unchecked use raises concerns we don’t talk about enough. Common PPIs include: Prilosec (omeprazole), Nexium (esomeprazole), Protonix (pantoprazole), Prevacid (lansoprazole), Dexilant (dexlansoprazole) PPIs do not clearly cause cancer — but long-term use has been associated with: • chronically elevated gastrin levels • altered stomach and gut microbiome • potential nitrosamine formation • masking s
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